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Hormones in Action

Assignment Goals
Source Material
Student Instructions
Guiding Questions
Writing Prompt

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Assignment Goals

This activity has the following goals:

  1. Explain the similarities and differences between protein-like hormones and steroid hormones, and relate their effects on cells to psychosocial challenges.
  2. Promote effective reading for understanding and answering the Guiding Questions.
  3. Analyze a primary research article to arrive at valid conclusions about content in the text, and apply these conclusions in the real world.
  4. Learn how to organize an essay with an instructional model provided by the Guiding Questions and Writing Prompt.
  5. Learn how to think more clearly and creatively from evaluating the writing examples of peers.

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Source Material

Study the following source material:

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Source Material Resources:
Glossary for Testosterone Research Article - This glossary provides a step-by-step explanation for the required research article on testosterone.
URL: http://cpr.molsci.ucla.edu/cpr/data/institutions/300010/001404400366/001604500552/perm/resources/res1/file/TESTGLOS.htm
Protein-like Hormone Function - This is a summary for the physiology of epinephrine, as an example for how water-soluble hormones affect the body.
URL: http://cpr.molsci.ucla.edu/cpr/data/institutions/300010/001404400366/001604500552/perm/resources/res2/file/HorWat.htm
Steroid Hormone Function - This is a summary for the physiology of testosterone, as an example for how fat-soluble hormones (steroids) affect the body.
URL: http://cpr.molsci.ucla.edu/cpr/data/institutions/300010/001404400366/001604500552/perm/resources/res3/file/HorFat.htm
Urban, R. J. et al. (1995) - This abstract from Medline, for a primary research article on testosterone, shows how both types of hormones above work together in muscle cells.
URL: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491931&form=6&db=m&Dopt=b
Evaluating Essays - This page provides guidance for scoring the quality of essays in CPR.
URL: http://cpr.molsci.ucla.edu/cpr/data/institutions/300010/001404400366/001604500552/perm/resources/res6/file/ScoreCPR.htm

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Student Instructions

There are several tasks to complete.

  1. Study the Source Materials carefully.

  2. Answer all Guiding Questions and write your essay from the Writing Prompt.

  3. Submit your essay to CPR. You will not be able to enter it after that time. Any student entering an essay and failing to complete the steps below will earn zero credit and lose 5 points for disrupting the CPR for the remaining students.
  4. Perform the calibration of the sample essays. Follow this with review of your peers’ essays and then your self-assessment.

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Guiding Questions

  1. How do protein-like and steroid hormones differ in location of their receptors in the cell. What principle for cell membranes and solubility of molecules explains this difference for both types of hormones?

  2. How do protein-like and steroid hormones differ in mechanism for their effects on cells?

  3. The binding of testosterone to its receptor inside muscle cells does not directly increase synthesis of proteins for contraction. How can administration of testosterone cause increased synthesis of contractile proteins inside muscle cells and, therefore, increase in muscle strength? [Hint: Insulin-like growth factor-1 or IGF-1 is a water-soluble hormone; the research article by Urban et al. (1995) details the process for you, together with its Glossary.]

  4. A knowledge claim is a conclusion supported by valid data. What is the main knowledge claim from the testosterone research study, stated as a conclusion by Urban et al. (1995)?

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Writing Prompt

Write a paragraph of 150-250 words on all aspects of testosterone function covered in the Guiding Questions, and apply this explanation to psychosocial challenges. Any quoted material in this essay earns zero credit; it must be entirely in your own words.

  1. Begin with the main knowledge claim from the testosterone research article, and acknowledge this article as the source of this knowledge.

  2. Explain the role of cell membranes in determining the difference in location of receptors for testosterone compared to IGF-1.

  3. Then, discuss the differences between testosterone and IGF-1 in their basic mechanisms for affecting a cell. Include in this discussion a summary for how testosterone ultimately promotes increase in muscle strength.

  4. Conclude the paragraph with three value claims based on the instructions below. Do not mention the "IGF-1 binding protein" studied in the research article. Acknowledge this article for any material you take from it to support your value claims.

    A value claim is a judgment for how beneficial something may be. For example, confirming that IGF-1 increases strength could give researchers a mechanism for improving strength in the elderly. Give a value claim (1) for testosterone administration in the elderly, and support it from the research article; (2) for the potential social value of giving testosterone to the elderly; and (3) for effectiveness and safety of testosterone versus old-fashioned exercise.

    Please be as creative as you desire for making these claims; the only "wrong" response here would be something totally unrealistic.

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    Bob Hyde 

    San Jose State University 

    and

     Nancy Pelaez
    MaSTERS, College of Natural Sciences and Mathematics
    California State University, Fullerton
    Copyright © 2000.  All rights reserved.
    Revised: July 09, 2000.