Katherine A. Kantardjieff

Personal

Katherine Ann Kantardjieff, Ph.D., M.S.

09.29.1957, Los Angeles, CA USA

POSITION TITLE

Professor of Chemistry and Biochemistry

Department of Chemistry and Biochemistry, California State University, Fullerton

Director, W.M. Keck Foundation Center for Molecular Structure

a. Professional Preparation

INSTITUTION AND LOCATION	DEGREE	YEAR(s)	FIELD OF STUDY
University of Southern California	B.S.	1979	Chemistry/Biology
University of California Los Angeles	M.S.	1984	Physical Chemistry
University of California Los Angeles	Ph.D.	1988	Physical Chemistry
University of California Los Angeles	Post Doc	1988-1989	Structural Biology

b. Appointments

Professor, Dept. of Chemistry and Biochemistry, CSUF, 2000 - present

Participating Guest, Lawrence Livermore National Laboratory, 1998 – present

Consulting Scientist, Dept. of Biochemistry and Biophysics, Texas A&M University, 2002-2003

Visiting Associate in Chemistry, California Institute of Technology, 1997 – 1998

Associate Professor, Dept. of Chemistry and Biochemistry, CSUF, 1995 – 2000

Visiting Scientist, Birkbeck College, University of London, 1995

Director, W.M. Keck Foundation Center for Molecular Structure, 1992 – present

Assistant Professor, Department of Chemistry and Biochemistry, CSUF, 1989 – 1995

Postdoctoral Fellow, Dept. of Chemistry and Biochemistry, UCLA, 1988 – 1989

Teaching Asst, Assoc. and Fellow, Dept. of Chemistry and Biochemistry, UCLA, 1982 – 1988

Instructor and Chair, Science Dept., Daniel Murphy High School, Los Angeles, CA, 1980 – 1982

Instructor, Mathematics Dept., Immaculate Heart High School, Los Angeles, CA, 1979 – 1980

c. Representative Publications

(38 published or in press) (undergraduate student co-authors *; Masters student co-authors #; REU student co-author underlined)

i. Most Closely Related to the Proposed Project

Kantardjieff, K.A., Vasquez, C.*, Castro, P.*, Warfel, N.M.*, Rho, B-S., Lekin, T., Kim, C-Y., Segelke, B.W., Terwiliger, T.C. and Rupp, B. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: A persistence gene and protein drug target. Acta Cryst D61:355-364 (2005)
K.A. Kantardjieff and B. Rupp. Structural bioinformatic approaches to the discovery of new antimycobacterial drugs. Curr. Pharm. Des. 10(26): 3195-3211 (2004).
K.A. Kantardjieff, C-Y Kim, C. Naranjo, G.S. Waldo, T. Lekin, B.W. Segelke, A. Zemla, M.S. Park, T.C. Terwilliger and B. Rupp. Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway. Acta Crystallogr. D60: 985-902 (2004).
Reddy, V., S. Swanson, J.C. Sacchettini, K.A. Kantardjieff, B.W. Segelke, and B. Rupp. Effective electron density improvement and structure validation on a Linux multi-CPU web cluster: The TB Structural Genomics Consortium Bias Removal Web Service. Acta Cryst D(59): p. 2200-2210 (2003).
Cohen, A., Barnes, D., Bruick, R.K., Kantardjieff, K.A., Fowler, S., Efuet, E. and Mayfield, S.P. Identification and characterization of a model RNA binding protein that associates with the 5'-untranslated region of the chloroplast psbA mRNA. Biochemistry. 43: 8541-8550 (2004).

ii. Other Significant Papers

Kantardjieff, K.A., Jamshidian, M. and B. Rupp, Distributions of pI vs pH provide prior information for the design of crystallization screening experiments. Bioinformatics, 2004. 20(14): p. 2171-2174.
Katherine A. Kantardjieff and Bernhard Rupp. Protein isoelectric point as a predictor for increased crystallization screening efficiency. Bioinformatics. 20(02004): 1-7 (2004).
Segelke, B.W., J. Schafer, M.A. Coleman, T.P. Lekin, D. Toppani, K.J. Skowronek, K.A. Kantardjieff, and B. Rupp, Laboratory scale structural genomics. J Struct Funct Genomics, 2003. 5: p. 147-157.
K. Kantardjieff and B. Rupp. Matthews coefficient probabilities: improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complexes. Prot. Sci. 12(9): 1865-1871 (2003).
Kantardjieff, K.A., P. Hoechtl, F.-M. Tao, B.W. Segelke, and B. Rupp, Concanavalin A in a dimeric crystal form: revisiting structural accuracy and molecular flexibility. Acta Cryst D(58): p. 735-743 (2002).

iii. Recent Coordinate Depositions with Student Co-authors

PDB ID 1W30 Kantardjieff, K., Vasquez, C.*, Rupp, B. “PyrR from Mycobacterium tuberculosis”
PDC ID Hold Kantardjieff, K., Shen, M.#, Rupp, B. “High resolution structure of Tetanus Toxin Heavy Chain C-Fragment Gold Derivative”
PDC ID Hold Kantardjieff, K., Shen, M.#, Rupp, B. “High Resolution Structure of Tetanus Toxin Heavy Chain C-Fragment”
PDB ID 1EA8 Rupp, B., Peters-Libeu, C., Verderame, J., Kantardjieff, K. “Apolipoprotein E3 22Kd Fragment Lys146Glu Mutant”
PDB ID 1H7I Rupp, B., Peters-Libeu, C., Verderame, J., Kantardjieff, K. “Apolipoprotein E3 22Kd Fragment Lys146Gln Mutant”

d. Synergistic Activities

Continuing Education Committee, American Crystallographic Association (2003 – 2006); ACA AIP Liason (2003-6); CSU/UC Mathematics Diagnostic Testing Project (2002 – 2004); International Union of Crystallography Teaching Commission (2003 – 2009); United States National Committee for Crystallography, Chair, Education Subcommittee (NAS/NRC) (2000 – 2006), Vice-Chair (2006-2009), Chair (2009-2012); Advisory Board, Bioinformatics Certificate Program, CSUF (2000 – present); Governing Board/Faculty Consensus Group, CSU Program for Education and Research in Biotechnology (1999 – present); ACS, So. Cal. Executive Committee (1996 – 2001); Editorial Board J Chem Cryst (2004-present); Co-Editor J Appl Cryst, Teaching and Education (2006-2009); Ad hoc reviewer Prot Sci, J Biol Chem, J Bacteriol, J Chem Ed, Chem Educ, J Chem Cryst, Acta Crystallogr C, D, Bioorg Med Chem, Cell Biochem Biophys; Ad hoc and panel reviewer NSF, NIH, PRF; Instructor, EMBO PEPC4 Course (2002, 2004); Scholarly and Creative Activity Recognition, CSUF (1996, 1998, 2001, 2004); Who’s Who of American Teachers (2000); Fankuchen Memorial Award, ACA, Nomination (2000); Women in Technology Hall of Fame, Nomination (1997); CNSM-CSUF Outstanding Teaching Award (2003);

e. Collaborators & Other Affiliations

i. Current collaborators

Bernhard Rupp, qed life science discoveries; Steven R. Herron, Chemistry/ Biochemistry BYU; Christopher Meyer, Chemistry/Biochemistry CSUF; Fu-Ming Tao, Chemistry/ Biochemistry CSUF; Chandra Srinivasan Chemistry/Biochemistry CSUF; Marcelo Tolmasky, Biological Sci CSUF; Amy Beth Cohen, Biological Sci CSUF; James Sacchettini, Biochemistry and Biophysics/Chemistry Texas A&M University; L. Jeanne Perry, UCLA-DOE Protein Expression Laboratory; Guy Crundwell, Chemistry, Central Connecticut State University; Allen Hunter, Chemistry, Youngstown State University; E.J. Crane, Chemistry/Biochemistry Pomona College; Adam Johnson, Chemistry/Biochemistry, Harvey Mudd College; Ken Nakayama, Roger Acey, Chemistry/Biochemistry CSULB; Clyde Smith, SSRL

ii. Mentors

Ph.D. Advisor: David S. Eisenberg, Chemistry and Biochemistry, UCLA

Postdoctoral Advisor: David S. Eisenberg, Chemistry and Biochemistry, UCLA

Sabbatical Directors: Douglas C. Rees, Chemistry and Chemical Engineering, Caltech; Jacqueline K. Barton, Chemistry and Chemical Engineering, Caltech; James Sacchettini, Texas A & M University Participating Guest Director: Bernhard Rupp, BBRP, LLNL

iii. Thesis Advisor and Postgraduate Scholar Sponsor

Total number of post-docs supervised: 4 (3 in last 5 years)

Herb Axelrod, Guy Crundwell, Brian Schick, Steven Herron, Xiang (Sean) Ouyang

Total number of Masters theses completed: 7

Laura Ramirez, Eric Reinheimer, Dmitry Pervitsky, Gorogot Wisedchaisri, Thaddeus Norman, Russell Cramm, Vanessa Valverde

Total number of Masters theses in progress: 4

Macy Shen, James Ongaro, Ricky Lai, Matthew Nixt

Total number of graduate students advised: 18 (15 in last 5 years; 4 from sister campuses)

Total number of undergraduate students advised: ~145 (30 last five years)

Total number of high school interns supervised: 8 in last five years

Total presentations made by undergraduates at national and regional meetings (last 5 years): 40