Physical Biochemistry (Chemistry 543)
Methods in Molecular Biophysics: Structure, Dynamics, Function
Course Description here.
(includes expected outcomes, grading rubrics and policies)
Selected Readings, Notes, Assignments and Solutions are found on
www.CollegeBrain.net (requires registration)
Course Outline
| Week:Class | Reading | Assignments |
| 0:0 | Part A: Biological macromolecules and physical tools | You are expected to read Part A on your own before class officially begins. |
| 1: August 25,27 | Part B: Mass spectrometry | |
| 2: September 3 | Part C1: Thermodynamics | |
| 3: September 8,10 | Part C2,3: DSC and ITC | Assignment 1 due |
| 4: September 15 | Part C4: Plasmon resonance | |
| 4: September 17 | Part D1,2: Biological molecules as hydrodynamic particles | Assignment 2 due |
| 5: September 22 | EXAM 1 | |
| 5: September 24 | Part D3,4: Macromolecular diffusion, Analytical ultracentrifugation | |
| 6: September 29, October 1 | Part D5,6,7: Electrophoresis, Birefringence | |
| 7: October 7,9 | Part D8,9: Fluorescence depolarization, Viscosity; Part D10,11: Dynamic light scattering, Fluorescence correlation spectroscopy | Assignment 3 due |
| 8: October 13,15 | Part E: Optical spectroscopy | |
| 9: October 20,22 | Part F1,2,3: Light microscopy, atomic force microscopy, fluorescence microscopy | |
| 10: October 27,29 | Part F4,5: Single molecule methods | |
| 11: November 3,5 | Part G: X-ray diffraction | Assignment 4 due |
| 12: November 10,12 | Part G,H: Neutron and Electron diffraction | |
| 13: November 17 | EXAM 2 | |
| 13: November 19 | Part I: Molecular dynamics | |
| 14: November 24-28 | Thanksgiving recess | |
| 15: December 1,3 | Part J: Nuclear magnetic resonance | Assignment 5 due |
| 16: December 8,10 | Electron paramagnetic resonance | |
| 17: December 15-19 | Final examinations | Research Proposal due no later than Friday, December 19, 4:30pm |